N2-Dimethylguanosine
CAS No.:2140-67-2
Modified nucleoside synthon.
N2-Dimethylguanosine
2'-Deoxy-4-desmethylwyosine
CAS No.:101803-00-3
A convenient synthon for the preparation on N-2-alkyl derivatives of 2'-deoxyguanosine.
5-Methyl-2'-deoxycytidine Hydrochloride
CAS No.:838-07-3 (Free Base) 5241-10-1 (HCl Salt)
Modified nucleoside synthon.
2-Methyladenosine
CAS No.:16526-56-0
Modified nucleoside synthon.
N6-Benzoyl-5'-O-(dimethoxytrityl)-8-oxo-2'-deoxyadenosine
CAS No.:142979-41-7
Modified nucleoside synthon.
α-2'-Deoxyguanosine
CAS No.:19916-78-0
Modified nucleoside synthon.
5-Ethynyl-2'-deoxyuridine
CAS No.:61135-33-9
Modified nucleoside synthon.
1,3-Dimethylpseudouridine
CAS No.:64272-68-0
Modified nucleoside synthon.
5-Iodo-2'-deoxyuridine
CAS No.:54-42-2
Modified nucleoside synthon.
Pseudouridine (Fermentation)
CAS No.:1445-07-4
Fermented nucleoside synthon of the common RNA modification.
Tricyclic Nucleoside (TCN)
CAS No.:35943-35-2
Tricyclic nucleoside that is cell-permeable and inhibits phosphorylation, activation and signalling of Akt.
N1-Methyl-2'-deoxyguanosine
CAS No.:5132-79-6
Nucleosidic precursor with applications in enzymatic and chemical methylation, as well as Tm-leveling studies.
Tricyclic Nucleoside Monophosphate, (TCN-P)
CAS No.:61966-08-3
Inhibits Akt phosphorylation.
6-Methyl-3-(β-D-2-ribofuranosyl)pyrrolo[2,3-d]pyrimidin-2-one
CAS No.:644962-84-5
A fluorescent analogue of cytidine.
5-Iodotubercidin
CAS No.:24386-93-4
Competitive inhibitor of MAP kinase ERK2.
2-Fluoro-2'-deoxyadenosine
CAS No.:21679-12-9
Modified nucleoside synthon.
3',5'-Di-O-acetyl-5-fluoro-2'-O-methyluridine
CAS No.:869355-34-0
Modified nucleoside synthon.
5-O-Benzoyl-1,2-di-O-acetyl-3-deoxy-D-ribose
CAS No.:4613-71-2
Vorbruggen type ribosylation of an appropriate heterocycle with this sugar yields 3'-deoxynucleosides.
5-Amino-3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(3H,6H)-dione
CAS No.:122970-40-5
An antiviral and immuno-stimulatory agent.
5'-O-(p-Toluenesulfonyl)thymidine
CAS No.:7253-19-2
Reagent for the preparation of 5'-substituted cyclothymidine derivatives.
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Modified Nucleosides
Modified nucleosides are useful building blocks for DNA and RNA synthesis because they can alter the stability, function, and utility of an oligo, making them useful for a variety of applications.
Our uniquely large collection of modified nucleosides offers a diversity of properties such as fluorescence (e.g., Pyrrolo-dC, NACR1-350), immunostimulation (e.g., 5-Amino-3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(3H,6H)-dione, NACR1-366), enzyme inhibition (e.g., Tricyclic Nucleoside Monophosphate, NACR1-362), and altered base-pairing (2'-Deoxyisoguanosine, NACR1-071).
Highlights of modified nucleosides within our collection include:
- Bromo- and Iodo-modified nucleoside phosphoramidite precursors (Bromo: NACR1-001, NACR1-003; Iodo: NACR1-002, NACR1-004)
- 5-Hydroxymethyl-2'-deoxycytidine (NACN4-007), 5-Formyl-2’-deoxycytidine (NACN4-003), and 5-Hydroxy-2'-deoxycytidine (NACN4-004) for epigenetic studies
- Family of Pseudouridine analogues including Pseudouridine (Fermentation NACR1-348; Synthetic NACR1-368) and N1-Methypseudouridine (NACR1-311)
- Unnatural bases (dNaM, NACR1-304; d5SICS, NACR1-302) for expanding the genetic alphabet and “DNA damaged” nucleosides (e.g., 8-Oxo-2'-deoxyguanosine, NACR1-292; 8-Oxo-2'-deoxyadenosine, NACR1-291)