3'-Deoxy-3',4'-didehydro-5-ethynylcytidine
CAS No.:1823793-27-6
Modified nucleoside synthon.
3'-Deoxy-3',4'-didehydro-5-ethynylcytidine
3-β-D-ribofuranosyl-pyrrole-2
CAS No.:16755-07-0
Modified nucleoside synthon.
2,6-Bis-O-[2-(4-nitrophenyl)ethyl]-2'-deoxyxanthosine
Modified nucleoside synthon.
Sangivamycin (4-Amino-7-(B-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carboxamide)
CAS No.:18417-89-5
Modified nucleoside synthon.
5'-Azido-2',5'-dideoxycytidine
CAS No.:4803-88-7
Modified nucleoside synthon.
1-(α)-Chloro-3,5-di-O-(p-toluoyl)-2-deoxy-D-ribose
CAS No.:4330-21-6 or 3601-89-6
Versatile carbohydrate derivative universally used for the preparation of 2'-deoxy nucleosides.
2'-Deoxyisoguanosine
CAS No.:106449-56-3
Isomeric with dG, differing by transposition of the carbonyl group at position 6 with the C-NH2 group at position 2, providing a novel hydrogen bond donor/acceptor pattern.
7-Deaza-7-octadiynylinosine
Modified nucleoside synthon.
5-(1,7-Octadiyn-l-yl)-2'-deoxyuridine
CAS No.:909398-18-1
Nucleoside useful in Click Chemistry reactions.
2',3'-Didehydro-3'-deoxythymidine (d4T)
CAS No.:3056-17-5
2',3'-Didehydro-2',3'-dideoxynucleosides (d4Ns) display antiviral activity.
5-[3-(Trifluoroacetamido)-1-(E)-propenyl]uridine
CAS No.:869222-68-4
Modified nucleoside synthon.
3'-Deoxy-3',4'-didehydrocytidine
CAS No.:1823793-27-6
Modified nucleoside synthon.
5-(1-Propynyl)-2'-deoxycytidine
CAS No.:117693-24-0
Modified nucleoside synthon.
6-Thio-2'-deoxyguanosine
CAS No.:789-61-7
Modified nucleoside synthon.
N6-(6-Aminohexyl)-2'-deoxyadenosine
CAS No.:147218-60-8
Modified nucleoside synthon.
N6-Methyl-2'-O-Methyladenosine
CAS No.:57817-83-1
Modified nucleoside synthon.
2-Amino-4-chloro-7-(β-D-2-deoxyribofuranosyl)pyrrolo[2,3-d]pyrimidine
CAS No.:104291-17-0
Modified nucleoside synthon.
N4-Methylcytidine
CAS No.:10578-79-7
Modified nucleoside synthon.
6-Aza-2'-deoxyuridine
CAS No.:20500-29-2
Has a nitrogen atom in place of the methine group at position 6 of the uracil ring.
5'-O-Methylthymidine
CAS No.:14504-60-0
Modified thymidine synthon.
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Modified Nucleosides
Modified nucleosides are useful building blocks for DNA and RNA synthesis because they can alter the stability, function, and utility of an oligo, making them useful for a variety of applications.
Our uniquely large collection of modified nucleosides offers a diversity of properties such as fluorescence (e.g., Pyrrolo-dC, NACR1-350), immunostimulation (e.g., 5-Amino-3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(3H,6H)-dione, NACR1-366), enzyme inhibition (e.g., Tricyclic Nucleoside Monophosphate, NACR1-362), and altered base-pairing (2'-Deoxyisoguanosine, NACR1-071).
Highlights of modified nucleosides within our collection include:
- Bromo- and Iodo-modified nucleoside phosphoramidite precursors (Bromo: NACR1-001, NACR1-003; Iodo: NACR1-002, NACR1-004)
- 5-Hydroxymethyl-2'-deoxycytidine (NACN4-007), 5-Formyl-2’-deoxycytidine (NACN4-003), and 5-Hydroxy-2'-deoxycytidine (NACN4-004) for epigenetic studies
- Family of Pseudouridine analogues including Pseudouridine (Fermentation NACR1-348; Synthetic NACR1-368) and N1-Methypseudouridine (NACR1-311)
- Unnatural bases (dNaM, NACR1-304; d5SICS, NACR1-302) for expanding the genetic alphabet and “DNA damaged” nucleosides (e.g., 8-Oxo-2'-deoxyguanosine, NACR1-292; 8-Oxo-2'-deoxyadenosine, NACR1-291)