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Native CPG

Native CPG that be functionalised with a linker and either a base or a modifier, for solid-supported oligonucleotide synthesis.

Native CPG

Controlled Pore Glass (CPG) has been widely used as a solid support for oligo synthesis for several decades—and LGC, Biosearch Technologies’ Prime CPG is considered to be the gold standard across all sectors of the market.

Native, unfunctionalised, CPG is available for research purposes in a variety of pore sizes. It can be functionalised with a linker and either a base or modifier for solid-supported oligonucleotide synthesis.

LGC, Biosearch Technologies has perfected CPG manufacturing for maximum oligo purity and yield.

  • Our collaborative process has resulted in solid supports optimised for the synthesis of the latest therapeutic oligo classes including LNA, delivery enhancing lipid ligands, SiRNA and Spiegelmers.
  • Our advanced CPG production techniques improve control of particle size and shape, pore size, pore volume and specific surface area, increasing the efficiency, purity and reproducibility of syntheses.
  • Our CPG is considered to be the gold-standard solid support used in all sectors of the market.

Five pore sizes are offered, 500 Å, 600 Å, 1000 Å, 1400 Å, and 2000 Å, enabling the synthesis of oligonucleotides for all applications. Which pore size is required is dependent on the length, complexity and application of the oligo. Some guidelines are below for the most widely used pore sizes.

Several pore sizes are offered from 500 Å to 3000 Å to enable the synthesis of oligonucleotides for all applications. Which pore size required is dependent on the length, complexity and application of the oligo. Some guidelines are below for the most widely used pore sizes. 

CPG Description
500 Å CPG
  • ≤30mers medium to large scale oligo synthesis 
  • High yields of product are required such as therapeutic oligos 
  • Standard (35-50 μmol/g) and High (60-100 μmol/g) loading varieties
  • High loaded support is required. 500 Å can load up to ~100 μmol/g 
1000 Å CPG
  • >20mers or highly modified oligonucleotides
  • The loading is typically 25-40 µmol/g and most of our modifiers are functionalised onto this pore size as standard
3000 Å CPG
  • >80mers 
  • The loading is typically 10-25 µmol/g. 
  • With a few exceptions, it is possible to have any of our 1000 Å products with a 3000 Å pore size

In general, large scale oligo synthesis for therapeutic applications requires high loaded 500-600 Å and small to medium scale synthesis for diagnostic or research use require higher pores sizes.