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OmniCleave Endonuclease

A robust, flexible endonuclease for the removal/digestion of all types of RNA and DNA leaving only di-, tri- and tetranucleotides behind.

Exonuclease III

Item Id: EX4425K

Digest duplex DNA in a 3´ to 5´ direction from a nick, blunt end, or 3´-recessed end, producing stretches of ssDNA.

Rec J Exonuclease

Item Id: RJ411250

Magnesium-dependent exonuclease for 5' to 3' digestion of single-stranded DNA.

Baseline-ZERO DNase

Item Id: DB0715K

Digest large or small DNA molecules better than standard DNase I.

RNase I

Item Id: N6901K

Completely digest single-stranded RNA with this heat-labile, non-sequence specific RNase.

RNase A

Item Id: MRNA092

Efficiently degrade unwanted RNA in DNA preparations and other samples.

Exonuclease I, E. coli

Item Id: X40520K

An exonuclease that digests single-stranded DNA but not double-stranded DNA, in a 3' to 5' direction.

Ribonuclease R (RNase R)

Item Id: RNR07250

A 3´ to 5´ exoribonuclease that digests all linear RNAs except lariat or circular RNA structures.

Exonuclease VII

Item Id: EN510250

ssDNA exonuclease with both 5' to 3' and 3' to 5' exonuclease activities.


Digest unwanted DNA and RNA in cell lysates, protein preparations, enzymatic reactions, and other sample types and applications with our highly purified nucleases.

LGC, Biosearch Technologies offers a complete selection of high-purity DNA and RNA nucleases to keep your samples free from contaminating nucleic acids and your downstream assays running smoothly.

Our nucleases are suitable for a variety of applications ranging from standard DNases and RNases to highly specific exonucleases with 5’ to 3’ and 3’ to 5’ activity to thermostable RNases that degrade RNA in a DNA:RNA hybrids.

We understand your project is unique, so to meet your specific requirements, we can customize the concentration, formulation, dispensing, packaging and labeling – including private labeling – of DNA and RNA nucleases. And, we’ll also provide knowledgeable scientific support for your project from start to finish.

With LGC, Biosearch Technologies, you can speed your development with responsive manufacturing, rapid order turnaround, and on-time delivery.

  • Use our in-house expertise in a broad array of enzyme classes, applications,
  • and technologies
  • Leverage our quality with our ISO 13485-certified quality system
  • Proceed with confidence as our scientists support your project at every step
  • Complete your workflow with our diverse offering of enzymes for molecular biology - from polymerases and proteases to Cas9 Nuclease