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5'-HydrAzide-Modifier-6 CE-Phosphoramidite

5'-HydrAzide-Modifier-6 CE-Phosphoramidite

CAS No.: 350716-21-1

Allows incorporation of a useful hydrazine moiety for post-synthetic modification of oligonucleotides, with spacer.
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Product information

Hydrazides have been useful tools in protein and carbohydrate chemistry, and more recently in oligonucleotide bioconjugation.(1) The lack of easily available hydrazide-containing phosphoramidite building blocks has impeded more widespread use of these tools in the post-synthetic modification of oligonucleotides. In addition to our amino modifier and aminooxy phosphoramidites, we offer two hydrazide modifier phosphoramidites, BA0384 and BA0385, the former with a spacer for use with post-synthetic covalent attachment chemistry. Both products employ non-methoxy trityl (Tr) protection.

Ref:

  1. (a) Raddatz, S.; Mueller-Ibeler, J.; Kluge, J.; Wab, L.; Burdinski, G.; Havens, J. R.; Onofrey, T. J.; Wang, D.; Schweitzer, M. Nucleic Acids Research, 2002, 30 (21) 4793-4802. (b) Antsypovich, S. I.; Oretskaya, T. S.; von Kiedrowski, G.; Rus. Chem. Bull. Int. Ed. 2005, 54, 2671-2681.
Brand Berry
Type Phosphoramidites
Sequence 5'

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