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  4. DNA and RNA Oligonucleotide Synthesizers

MerMade, 96 Well Format of Columns

Item Id: AXMM96E

The MerMade 96E Oligonucleotide synthesizer is designed to synthesize DNA, RNA & LNA oligonucleotides in a column format using standard or modified chemistries. 

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Mermade 6 Synthesizer

The MerMade 6 Oligonucleotide synthesizer is designed to synthesize DNA, RNA and LNA oligonucleotides in a column format using standard or modified chemistries.

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Mermade 12 Synthesizer

The MerMade 12 Oligonucleotide synthesizer is designed to synthesize DNA, RNA and LNA oligonucleotides in a column format using standard or modified chemistries.

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Mermade 48X Synthesizer

The MerMade 48X Oligonucleotide synthesizer is designed to synthesize DNA, RNA & LNA oligonucleotides in a column format using standard or modified chemistries. 

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MerMade 4 Column Positions (2020 Model)

Item Id: AXM4

The MerMade oligonucleotide synthesizer is designed to synthesize DNA, RNA and LNA oligonucleotides in column format using standard or modified chemistries.

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MerMade 192E, 96 Well Format of Columns

Item Id: AXMM192E

The MerMade 192E Oligonucleotide synthesizer is designed to synthesize DNA, RNA & LNA oligonucleotides in a column format using standard or modified chemistries. 

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DNA and RNA Oligonucleotide Synthesizers

Synthesize DNA, RNA and LNA oligonucleotides in a column format using standard or modified chemistries with a MerMade™ oligo synthesizer. The MerMade oligo synthesizers are designed to synthesise DNA, RNA and LNA oligonucleotides in a column format using standard or modified chemistries. They have been used worldwide to generate millions of high quality DNA and RNA oligonucleotides for a wide variety of applications, such as gene building, PCR, aptamer creation, hybridization, sequencing and antisense studies.

The MerMade oligo synthesizers are the preferred choice among academic institutions, national laboratories and pharmaceutical companies.

  • Reliable
  • Flexible and customisable
  • High-throughput capable
  • Scalable 
  • Cost-efficient reagent use
  • Easy-to-use software 

Whether you need to synthesise a few custom oligos a week or several thousand a day, we have a MerMade that will meet your needs.

Key features of MerMade oligo synthesizers

Standard features Optional features Unique features (dependent on specific synthesizer)
  • Mixed backbone capability (phosphorothioate and phosphodiester)
  • Pre-loaded with standard protocols
  • Cleavage apparatus included
  • Flexible and easy-to-use software that runs on Windows 7 and 10
  • Dell PC and monitor included with extended warranty
  • Run log of all synthesis carried out on synthesizer
  • Customised number of amidite/reagent ports
  • Custom integration of software with in house LIMS
  • Multiple reagent cap adapters
  • Uninterruptible power supply back up to allow synthesis recovery in the event of power loss
  • A fully featured API for remote monitoring and control
  • Barcode reader
  • Argon pressure sensor
  • Trityl monitoring
  • Low dead volume bottle mount for expensive modifiers

Comparing the MerMade family of oligo synthesizers

Oligo synthesizer Throughput Columns format Max Amidite positions (standard) Typical run times Scale
MerMade 4 low 4 10 20mer primers in 3 hours on each column 50 nmole to 5 μmol
MerMade 6 medium 6 20 (10) < 2 hours for 12 columns of DNA 20mers 50 nmole to 200 μmol (over 400 μmo with certain supports)
MerMade 12 medium 12 20 (10) < 2 hours for 12 columns of DNA 20mers 50nmole to 200 μmo (over 400 μmo with certain supports)
MerMade 48X high 4 plates of 12 oligos >20 (20)  48 oligos in less than 2 hours 20 nmole to 5 μmol
MerMade 96E high 96 well format of columns 14 (10) 96 oligos in less than 2 hours 20 nmole to 5 μmol
MerMade 192X high 96 well format of columns 64 (12)  192 oligos in less than 3 hours (assuming minimal modifications) 20 nmole to 5 μmol
MerMade 192E high 96 well format of columns 64 (8)  192 oligos in less than 3 hours (assuming minimal modifications) 20 nmole to 5 μmol

Oligo synthesizer options

Product Benefit
MerMade 4 Each of the four columns can be assigned a different protocol to synthesise oligos of different quality and yield within the same run.
MerMade 6 Capable of making a combination of standard, degenerate and modified oligos in the same run. Unmatched flexibility, upgrade ability, dependability, efficiency and ease of use.
MerMade 12 Ideal for labs requiring medium throughput with maximum flexibility. Capable of making a combination of standard, degenerate and modified oligos in the same run.
MerMade 48X A fast oligo synthesizer that is capable of producing high quality oligos—even those with extensive modifications. Allows for hot swapping plates as the synthesis is completed to facilitate a continuous, efficient operation.
MerMade 96E Ideally suited for labs that need a fast synthesizer that can be configured for all types of chemistry and is capable of producing high-quality oligos.  
MerMade 192X This oligo synthesizer adds even more flexibility, configurability and speed compared to models listed above. It can be configured to synthesise all types of chemistries and produces high-quality oligos.
MerMade 192E Produces a very high-quality product with very minimal reagent usage. Ideal for those who need a fast synthesizer that is capable of producing high-quality oligos that do not require extensive modifications.