3'-Thiol-C3 CNA CPG Low Bulk Density
3'-Thiol-C3 CNA CPG Low Bulk Density
3'-Thiol-C3 CNA CPG Low Bulk Density, 600 Å, 41-59 µmol/g, BULK (g)
Key features
Show- Thiol modification allows post-synthetic conjugation of oligonucleotides to reporter labels.
- Standard bulk density 0.25-0.33 g/cc.
- Shorter C3 spacer.
Usually shipped in 4+ Weeks, Made To Order
Product information
Incorporation of a thiol reactive functional group at specific sites within an oligonucleotide allows for subsequent post-synthesis conjugation of the oligo with a number of different moieties such as fluorescent markers and biotin, depending on the application. Such labels need to be reactive towards the incorporated functional group: for example, thiols will react with iodoacetate and maleimide derivatives to form thioether linkages. The 3'-thiol-modifier CPGs with C3 and C6 S-S linkers can be used to introduce a 3'-thio functionality, with subsequent cleavage of the disulphide linkage affording the free thiol. This is then available for conjugation.
Access support
Need some support with placing an order, setting up an account, or finding the right protocol?
Contact us