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  4. Modified Nucleoside Phosphoramidites
  5. 8-Aza-7-deaza-dA CE-Phosphoramidite

8-Aza-7-deaza-dA CE-Phosphoramidite

8-Aza-7-deaza-dA CE-Phosphoramidite

8-Aza-7-deaza-dA CE-Phosphoramidite

Isosteric with adenine but offers a different pi-electron distribution and thus an altered dipole moment.
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Oligonucleotides containing 8-aza-7-deaza-dA residues exhibit higher Tm's due to stronger base stacking interactions.(1)

Ref:

  1. Seela, F.; Kaiser, K. Helv. Chim. Acta 1988, 71, 1813-1823.

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