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UnyLinker™ CPG, DMT on (N-Ph)

UnyLinker™ CPG, DMT on (N-Ph), 500 Å, Bulk (g)

UnyLinker™ CPG, DMT on (N-Ph)

UnyLinker™ CPG, DMT on (N-Ph), 500 Å, Bulk (g)

Universal CPG solid support for oligonucleotide synthesis.

Key features

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- Manufactured using our Next Generation native CPG process

- Optimized density and loading range to maximize FLP (full length product) yield

- Contains DMT functionality

Option 1: Select a Pore Size
Option 2: Select a Functional Loading
Option 3: Select a Size
Item ID BG8-1001-B
TBD
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Min order quantity10

Product information

A 'universal' support in the context of oligonucleotide synthesis is a solid support, normally either a controlled-pore glass (CPG) or polystyrene (PS), where no functionality (e.g. nucleobase or modification) of the support is retained at the 3' end of the oligo sequence after cleavage. In this case, the first addition at the 3'-end is determined by the first phosphoramidite used in the synthesis cycle. There are advantages in using a ‘universal’ support where there is no nucleobase or modification already present (e.g. when using plate synthesizer). When preparing wells in plate synthesizers this eliminates the possibility of the incorrect resin being placed in a well. It also allows automated preparation of the plates to stock ready for synthesis. There is also an added benefit in large-scale syntheses, where the supply chain is simplified as only the one support is required.

A universal support can also be applied in situations where a 3'-modification support is not available, using a phosphoramidite modifier as the first addition in the cycle (this will only work with phosphoramidites capable of extending the oligo chain, i.e. not 5' chain-terminating modifiers). In all cases, the oligo sequence and any modifications incorporated must be compatible with the universal support cleavage and deprotection conditions for the use of an universal support to be viable. This is one reason why a universal support may not always be the optimum choice for synthesis.

In our commitment to offering an optimal range of universal CPG products, we offer both the industry-standard UnyLinker™ CPG, plus an analogous DMT-OFF / N-iPr product. Our UnyLinker™ 500Å CPG has been designed and manufactured with optimized density and loading specifications, using our Next Generation native CPG processes. As such, it offers unrivalled performance for a universal CPG.

 

UnyLinker™ is a trademark of Ionis Pharmaceuticals, Inc. and used under licence.

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