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dC (Bz) CNA CPG Low Bulk Density

dC (Bz) CNA CPG Low Bulk Density

CPG for incorporation of unmodified dC at 3' end of an oligonucleotide.

Key features

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  • Longchain alkylamino linker
  • Low bulk density 0.200.24 g/cc
  • Prime CPG suitable for customers with largescale or therapeutic development requirements
Option 1: Select a Pore Size
Option 2: Select a Functional Loading
Option 3: Select a Size
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Product information

Controlled Pore Glass (CPG) has been widely used as a solid support for oligo synthesis for several decades. LGC, Biosearch Technologies’ has perfected CPG manufacture for maximum oligo purity and yield. Our advanced CPG production techniques were developed originally in our Prime Synthesis business to improve control of particle size and shape, pore size, pore volume, and specific surface area. These physical parameters influence solution exchange behaviour, ligand loading and distribution, and reaction kinetics to increase the efficiency, purity, and reproducibility of syntheses. Proprietary chemical attachment procedures were developed to further optimise ligand distributions, providing increased accessibility to synthesis reagents and washing solutions and facilitating even better oligo yields and purities. Furthermore, process refinements and proprietary assays were developed to minimise the troublesome “N-1” impurity levels in an oligo synthesis. LGC, Biosearch Technologies’ CPG is considered to be the gold-standard solid support used in all sectors of the market.

Our collaborative process has resulted in solid supports that are optimised for the synthesis of the latest therapeutic oligo classes including LNA, delivery enhancing lipid ligands, siRNA and Spiegelmers. Our CPG solid supports are available in a variety of pore sizes and functionalised nucleoside loadings. Which pore size and loading required is dependent on the length, complexity and application of the oligo. 500 Å and 600 Å CPG is suited to ≤30mers in medium to large scale oligo synthesis, where high yields of product are required such as for therapeutic oligos. 500 Å CPG can load up to ~100 μmol/g. 1000 Å CPG is suited to >20mers synthesis or for highly modified oligonucleotides. Most of our modifier CPGs are functionalised onto this pore size as standard. 2000 Å CPG offers the ability to synthesise longers oligos, whilst retaining higher loading (yield) possibilites of lower pore sizes. 2000 Å CPG is typically used in CRISPR applications. 3000 Å CPG is suited to longer oligos (>80mers). With a few exceptions, it is possible for us to manufacture any of our 1000 Å products with a 3000 Å pore size on a custom basis. Our Prime Synthesis bulk CPGs are manufactured with either an aminopropyl (AMP) or long-chain alkyl amino (CNA) linker, denoted in the product name.

Synthesizer
Column
Type/Description
Notes
MerMade 6,12
MerMade, syringe (all scales)
Pipette type column
A MerMade column is also known as a Supercolumn
MerMade 4, 48X, 96E, 192E, 192X
MerMade, Syringe (up to 1.3 mL)
Pipette type column
A MerMade column is also known as a Supercolumn
ABI 384 / 394
Luer
Barrel column with luer fitting at either end
Also known as ALL-FIT or Standard
Expedite 8909
Luer
Barrel column with luer fitting at either end
Also known as ALL-FIT or Standard
ABI3900
MerMade
Pipette type column
A MerMade column is also known as a Supercolumn
K&A H4, H8, H8SE, H2, H32, H64
Luer
Barrel column with luer fitting at either end
Also known as ALL-FIT or Standard
K&A S4CL/S8CL
Luer
  Barrel column with luer fitting at either end 
 Also known as Standard. For this instrument, we recommend the Luer (Standard) column as the ALL-FIT columns have a wider barrel.
Dr Oligo 48
MerMade
Pipette type column
A MerMade column is also known as a Supercolumn
 Dr Oligo 192XLc, 768XLc just plates 
 MerMade, Syringe (up to 1.3 mL) 
Pipette type column
A MerMade column is also known as a Supercolumn
 OligoMaker X12, 48, 192, X192, X96 
MerMade, Syringe (up to 1.3 mL)
Pipette type column
A MerMade column is also known as a Supercolumn

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