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8-Br-dA (dmf) CE-Phosphoramidite

8-Br-dA (dmf) CE-Phosphoramidite

CAS No.:207906-54-5

Allows for incorporation of a halogenated nucleoside into oligonucleotides for crystallographic studies and crosslinking studies of protein-DNA and RNA-DNA complexes.
  • Part of the set of the four photoactive bases required to examine base to amino acid contact pairs (along with Br-dG, Br-dC and Br-dU).
  • dmf protection allows widest compatibility with deprotection conditions.
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For examples of Pd-catalyzed postsynthetic aryl couplings of C8-Br-G modified oligonucleotides, see Omumi, A.; Beach, D. G.; Baker, M.; Gabryelski, W.; Manderville, R.A. J. Am. Chem. Soc. 2011, 133, 42-50.

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