8-Br-dA (Bz) CE-Phosphoramidite
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8-Br-dA (Bz) CE-Phosphoramidite
Allows for incorporation of a halogenated nucleoside into oligonucleotides for crystallographic studies and crosslinking studies of protein-DNA and RNA-DNA complexes.
Key features
Show- Part of the set of the four photoactive bases required to examine base to amino acid contact pairs (along with Br-dG, Br-dC and Br-dU).
- Bz protection allows compatibility with standard deprotection conditions.
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Product information
Couples efficiently with extended coupling times and can be used for the incorporation of a halogenated nucleosides into oligonucleotides for crystallographic studies and crosslinking studies of protein-DNA and RNA-DNA complexes.
For examples of Pd-catalyzed postsynthetic aryl couplings of C8-Br-G modified oligonucleotides, see Omumi, A.; Beach, D. G.; Baker, M.; Gabryelski, W.; Manderville, R.A. J. Am. Chem. Soc. 2011, 133, 42-50.
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