The Sasaki labs have identified a variation of Matteucci’s cytosine analog “G-Clamp”⁽¹⁾ that is specific for 8-oxoG. This fluorescent phenoxazine analog 8-oxoG Clamp CEP (BA0339) appears to be highly specific for pairing with 8-oxoG.⁽²⁾ When incorporated into an oligonucleotide, the duplex stabilization was lowered only slightly, and 8-oxoG was selectively detected by fluorescence quenching the 8-oxoG Clamp.⁽³⁾

Ref:

1. Lin, K.-Y.; Jones, R.J.; Matteucci, M. J. Am. Chem. Soc., 1995, 117, 3873-3874.
2. Nakagawa, O.; Ono, S.; Li, Z.; Tsujimoto, A.; Sasaki, S. Angew. Chem. Int. Ed., 2007, 46, 4500-4503.
3. Nasr, T.; Li, Z.; Nakagawa, O.; Taniguchi, Y.; Ono, S.; Sasaki, S. Bioorg. & Med. Chem. Lett. 2009, 19, 727-730.