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- Useful for mutagenic studies involving oxidative processes or ionisation radiation.
- Classical isobutyryl protection.
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8-oxo-dG-CE Phosphoramidite allows investigation of the structure and activity of oligonucleotides containing an 8-oxo mutation. This is formed naturally when DNA is subjected to oxidative conditions or ionising radiation. The resulting 8-oxo modification is significant in mutagenesis and ultimately carcinogenesis.