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Abasic CNA CPG

Abasic CNA CPG

Abasic CNA CPG, 500 Å, 71-79 µmol/g, BULK (g)

CPG for the incorporation of an abasic spacer at the 3' end of an oligonucleotide.
  • Mimics the three carbon spacing between the 3’ and 5’ hydroxyls of the sugar unit.
  • Unlike C3, modifier sits directly in the natural sugar-phosphate backbone with no adverse effect.
  • Standard bulk density 0.25-0.33 g/cc.
Option 1: Select a Pore Size
Option 2: Select a Functional Loading
Option 3: Select a Size
Item ID BG7-1169-B
TBD
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Product information

A spacer C3 moiety, when incorporated into an oligonucleotide, mimics the three carbon spacing between the 3’ and 5’ hydroxyls of the sugar unit. Although useful where the base at a specific site is unknown, the flexibility of the alkyl chain distorts the sugar-phosphate backbone. This can be alleviated an abasic spacer since incorporation of this modifier sits directly into the natural sugar-phosphate backbone with no adverse effect. This modifier mimics abasic sites and is useful in the study of mutations resulting from depurination.

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