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G-Rich regions in nucleic acids often display disrupted Watson-Crick base-pairing due to the ability of dG and G residues to enter into non-Watson-Crick inter- and intramolecular hydrogen bonding. A solution to this problem is to replace the N7 nitrogen atom on the guanine nucleobase with a CH group, obviating the possibility of hydrogen bonding at that position. For studies on alternating d(G-C)3 and d(C-G)3 hexanucleotides containing 7-deaza-2'-deoxyguanosine or 8-aza-7-deaza-2'-deoxyguanosine (BA0242) in place of dG, see: Seela, F.; Driller, H. Nucleic Acids Res. 1989, 17(3), 901-910. We also offer 7-Deaza-G CEP (BA0323) for RNA synthesis.
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