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Hydrophilic Bz-S-TEG CE-Phosphoramidite

Hydrophilic Bz-S-TEG CE-Phosphoramidite

Phosphoramidite for the incorporation of a thiol function at the 5' end of an oligonucleotide, with a tetraethylene glycol spacer.
  • Incorporates a thiol reactive functional group for conjugation.
  • Suited to solution-phase couplings of labels to oligos. Has hydrophilicity "built-in" without need for separate spacer.
  • This product is not compatible with thiotetrazoles as activators therefore DCI is recommended for this modification.
  • Please note that we do not generally hold this product in stock, however it can be made to order. Please contact us for up to date availability and pricing information.
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Product information

Incorporation of a thiol reactive functional group at specific sites within an oligonucleotide allows for subsequent post-synthesis conjugation of the oligo with a number of different moieties such as fluorescent markers and biotin, depending on the application. Such labels need to be reactive towards the incorporated functional group: for example, thiols will react with iodoacetate and maleimide derivatives to form thioether linkages.

This hydrophilic thiol-modifier is particularly useful for solution-phase couplings of labels to oligos. It is often found that when using classic thiol-modifiers, e.g. thiol-C6 S-S, a hydrophilic spacer is required. This extends the distance of the label from the oligo. LK2187 has this hydrophilicity "built-in" and can therefore be used where hydrophilic linking is needed, but the distance of the label from the oligo requires to remain short.

This product is not compatible with thiotetrazoles as activators therefore DCI is recommended for this modification.

Brand LINK
Type Phosphoramidites
Modification Thiol
Sequence 5'

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