Skip to content Skip to navigation menu

3'-Thiol Modifier C6 S-S Glyc CPG

3'-Thiol Modifier C6 S-S Glyc CPG

3'-Thiol Modifier C6 S-S Glyc CPG, 1000 Å, Standard Loading, 1 g

CPG for the incorporation of a thiol function at the 3' end of an oligonucleotide, with a C6 spacer.
  • Incorporates a thiol reactive functional group for conjugation.
  • Longer C6 spacer.
  • Glycolate linker for rapid cleavage of the oligonucleotide.
Option 1: Select a Pore Size
Option 2: Select a Functional Loading
Option 3: Select a Size
Item ID BG1-5003-1
Add to basket to request a quote

Product information

Incorporation of a thiol reactive functional group at specific sites within an oligonucleotide allows for subsequent post-synthesis conjugation of the oligo with a number of different moieties such as fluorescent markers and biotin, depending on the application. Such labels need to be reactive towards the incorporated functional group: for example, thiols will react with iodoacetate and maleimide derivatives to form thioether linkages. The 3'-thiol-modifier CPGs with C3 and C6 S-S linkers can be used to introduce a 3'-thio functionality, with subsequent cleavage of the disulphide linkage affording the free thiol. This is then available for conjugation.

Access support

Need some support with placing an order, setting up an account, or finding the right protocol?

Contact us