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2-Thiouridine CE-Phosphoramidite

2-Thiouridine CE-Phosphoramidite

CAS No.: 163496-21-7

Phosphoramidite for the efficient incorporation of a 2-thiouridine modification into oligonucleotides.
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Substitution with sulfur at the 2-position of uridine provides a tool for the investigation of RNA duplex stability(1) and non-enzymatic(2) and ribozyme catalyzed RNA primer extension.(3)

Ref:

  1. (a) Kumar, R.K.; Davis, D.R. Nuc. Acid. Res. 1997, 25(6), 1272-1280. (b) Testa, S.M.; Disney, M.D.; Turner, D.H.; Kierzek, R. Biochem. 1999, 38, 16655-16662.
  2. Heuberger, B.D.; Pal, A.; Del Frate, F.; Topkar, V.V.; Szostak, J.W. J. Am. Chem. Soc., 2015, 137 (7), pp 2769–2775.
  3. Prywes, N.; Michaels, Y.S.; Pal, A.; Oh, S.S., Szostak, J.W. Chem. Commun. 2016. 52, 6529-6532.
Brand Berry
Base U
Modification Thiol
Sequence Internal

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