Key featuresShow Hide
- Incorporates a glyceryl functionality at 3' end of an oligo
- Glyceryl functionality is readily oxidized to an aldehyde or carboxylic acid, for conjugation to an amine.
- 500 Å CPG suitable for high yield applications such as therapeutic oligos (≤ 30mers).
- 1000 Å CPG suitable for highly modified oligonucleotides (> 20mers).
Cannot add to favourites
An option must be selected in order to add to favourites
Using glyceryl CPG, the 3'-end of an oligonucleotide is readily oxidized by sodium periodate to form a 3'-phosphoglycaldehyde. The aldehyde may be further oxidized to the corresponding carboxylic acid. Either the aldehyde or the carboxylate may be used for conjugation to amino-functionalised biomolecules. This is an effective strategy for 3' post-synthetic modification with amines, as 3'-functionalised carboxylate and aldehyde solid supports are not commonly available.