Key featuresShow Hide
- Incorporates a glyceryl functionality at 3' end of an oligo
- Glyceryl functionality is readily oxidized to an aldehyde or carboxylic acid, for conjugation to an amine.
- 500 Å CPG suitable for high yield applications such as therapeutic oligos (≤ 30mers).
- 1000 Å CPG suitable for highly modified oligonucleotides (> 20mers).
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Using glyceryl CPG, the 3'-end of an oligonucleotide is readily oxidized by sodium periodate to form a 3'-phosphoglycaldehyde. The aldehyde may be further oxidized to the corresponding carboxylic acid. Either the aldehyde or the carboxylate may be used for conjugation to amino-functionalised biomolecules. This is an effective strategy for 3' post-synthetic modification with amines, as 3'-functionalised carboxylate and aldehyde solid supports are not commonly available.
|Type||CPG - Bulk|