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3'-Glyceryl CPG Column

3'-Glyceryl CPG Column

CPG column for the incorporation of a glyceryl function at the 3' end of an oligonucleotide for eventual conjugation to amines.
  • Incorporates a glyceryl functionality at 3' end of an oligo
  • Glyceryl functionality is readily oxidized to an aldehyde or carboxylic acid, for conjugation to an amine.
  • 500 Å CPG suitable for high yield applications such as therapeutic oligos (≤ 30mers).
  • 1000 Å CPG suitable for highly modified oligonucleotides (> 20mers).
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Product information

Using glyceryl CPG, the 3'-end of an oligonucleotide is readily oxidized by sodium periodate to form a 3'-phosphoglycaldehyde. The aldehyde may be further oxidized to the corresponding carboxylic acid. Either the aldehyde or the carboxylate may be used for conjugation to amino-functionalised biomolecules. This is an effective strategy for 3' post-synthetic modification with amines, as 3'-functionalised carboxylate and aldehyde solid supports are not commonly available.

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