CAS No.: 1306615-51-9
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LKD4270 is a dual purpose linker that has numerous potential applications. Acylation of the oxyamine end affords a hydroxamic acid that bears a TEG-linked azide group. Hydroxamic acids have long been known to be useful as carboxylic acid mimics. Thus, an advantage of this product is that it allows the introduction of the TEG-azide functionality while retaining comparable acidity to the original carboxylic acid. Alternatively, it is possible for the oxyamine end to condense with an aldehyde, affording an oxime that bears a TEG-linked azide group. Subesquently, the azide group is available for use in a variety of well known ligation paradigms.
The purchase of this products for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry (“Click Chemistry”) includes a limited, nontransferable license to intellectual property owned by TSRI to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or email@example.com.