O6-Chlorophenyl-I CE-Phosphoramidite
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O6-Chlorophenyl-I CE-Phosphoramidite
O6-Chlorophenyl-I CE-Phosphoramidite, 250 mg, ABI (10 mL / 20 mm Septum)
CAS No.:220382-26-3
Convertible phosphoramidite that allows the formation of N6-alkyl-A residues in RNA.
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Product information
After incorporation of this unit into an oligoribonucleotide by standard phosphoramidite chemistry, treatment with ammonia, methylamine, or higher alkylamines, including those bearing tethered functional groups, leads to displacement of 4-chlorophenol with resultant installation of a 6-amino group, i.e., producing the desired N6-alkyl-A residues.(1)
Ref:
- Allerson, C. R.; Chen, S. L.; Verdine, G. L. J. Am. Chem. Soc. 1997, 119, 7423-7433.
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