O4-Chlorophenyl-U CE-Phosphoramidite
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O4-Chlorophenyl-U CE-Phosphoramidite
O4-Chlorophenyl-U CE-Phosphoramidite, 100 μmol, ABI (5 mL / 20 mm Septum)
CAS No.:220382-28-5
Convertible nucleoside phosphoramidite that allows the formation of N4-alkyl-C residues in RNA for structural studies.
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Product information
After incorporation of this unit into an oligoribonucleotide by standard phosphoramidite chemistry, treatment with ammonia, methylamine, or higher alkylamines, including those bearing tethered functional groups, leads to displacement of 4-chlorophenol with resultant installation of a 4-amino group, i.e., producing the desired N4-alkyl-C residues.(1)
Ref:
- Allerson, C. R.; Chen, S. L.; Verdine, G. L. J. Am. Chem. Soc. 1997, 119, 7423-7433.
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