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  4. Nucleoside Synthesis Reagents

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Nucleoside Synthesis Reagents

Use our reagents to generate reactive nucleosides for oligo synthesis. We have high-quality reagents for adding DMT and phosphoramidite functionality.

Nucleosides are prepared for oligonucleotide synthesis using 4,4'-dimethoxytrityl chloride for DMT-protection of the 5'-OH. The 3'-phosphoramidite functionality is achieved using a phosphitylating reagent in the presence of an activator, normally Diisopropylamine Hydrotetrazolide (DIHT). For ribonucleosides, or other cases where the 2’ position is hindered - or where rapid reaction is required, a more reactive chlorophosphitylating reagent is used in preference.

Reagent Description
Chlorophosphitylating agent
NACP3-001
  • Used to create reactive phosphoramidite functionality on nucleosides
  • Suitable for preparing reactive ribonucleosides
  • Faster reaction time than "Tetraphos"
4,4-Dimethoxytrityl Chloride
NACP3-002
  • Used to create reactive DMT functionality on nucleosides
  • Suitable for preparing reactive deoxy- and ribonucleosides
  • Non-hazardous for transport
Phosphitylating agent (Tetraphos)
NACP3-003
  • Used to create reactive phosphoramidite functionality on nucleosides 
  • Suitable for preparing reactive deoxynucleosides
  • Non-hazardous for transport
Diisopropylamine Hydrotetrazolide (DIHT)
NACP3-004​​​​​​​
  • Activator used in phosphoramidite synthesis

Explore our full range of nucleoside products to get exactly what you need.