Tricyclic Nucleoside (TCN)
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Tricyclic Nucleoside (TCN)
CAS No.:35943-35-2
Tricyclic nucleoside that is cell-permeable and inhibits phosphorylation, activation and signalling of Akt.
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Triciribine (a.k.a. TCN, Tricyclic Nucleoside, NSC-154020) inhibits Akt (protein kinase B) in a very selective fashion, resulting in apoptosis in human cancer cells.(1) It also inhibits DNA synthesis(2), and as its monophosphate, is active against HIV type 1(3)
Ref:
- Yang L, Dan HC, Sun M Liu Q, Sun X-m, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ, Cancer Research 2004, 64, 4394-4399.
- Wotring LL, Townsend LB, et. al, Cancer Res. 1990, 50, 4891-9.
- Ptak RG, Borysko KZ, Porcari AR, Buthod JL, Holland LE, Shipman C Jr, Townsend LB, Drach JC. AIDS Res. Hum. Retroviruses 1998, 14, 1315-22.
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