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Tricyclic Nucleoside (TCN)

Tricyclic Nucleoside (TCN)

CAS No.:35943-35-2

Tricyclic nucleoside that is cell-permeable and inhibits phosphorylation, activation and signalling of Akt.
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Product information

Triciribine (a.k.a. TCN, Tricyclic Nucleoside, NSC-154020) inhibits Akt (protein kinase B) in a very selective fashion, resulting in apoptosis in human cancer cells.(1) It also inhibits DNA synthesis(2), and as its monophosphate, is active against HIV type 1(3)


  1. Yang L, Dan HC, Sun M Liu Q, Sun X-m, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ, Cancer Research 2004, 64, 4394-4399.
  2. Wotring LL, Townsend LB, et. al, Cancer Res. 1990, 50, 4891-9.
  3. Ptak RG, Borysko KZ, Porcari AR, Buthod JL, Holland LE, Shipman C Jr, Townsend LB, Drach JC. AIDS Res. Hum. Retroviruses 1998, 14, 1315-22.

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