Modified nucleoside synthon.
A substrate for adenosine kinase.
Tricyclic nucleoside that is cell-permeable and inhibits phosphorylation, activation and signalling of Akt.
Inhibits Akt phosphorylation.
Modified nucleosides are useful building blocks for DNA and RNA synthesis because they can alter the stability, function, and utility of an oligo, making them useful for a variety of applications.
Our uniquely large collection of modified nucleosides offers a diversity of properties such as fluorescence (e.g., Pyrrolo-dC, NACR1-350), immunostimulation (e.g., 5-Amino-3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(3H,6H)-dione, NACR1-366), enzyme inhibition (e.g., Tricyclic Nucleoside Monophosphate, NACR1-362), and altered base-pairing (2'-Deoxyisoguanosine, NACR1-071).
Highlights of modified nucleosides within our collection include:
- Bromo- and Iodo-modified nucleoside phosphoramidite precursors (Bromo: NACR1-001, NACR1-003; Iodo: NACR1-002, NACR1-004)
- 5-Hydroxymethyl-2'-deoxycytidine (NACN4-007), 5-Formyl-2’-deoxycytidine (NACN4-003), and 5-Hydroxy-2'-deoxycytidine (NACN4-004) for epigenetic studies
- Family of Pseudouridine analogues including Pseudouridine (Fermentation NACR1-348; Synthetic NACR1-368) and N1-Methypseudouridine (NACR1-311)
- Unnatural bases (dNaM, NACR1-304; d5SICS, NACR1-302) for expanding the genetic alphabet and “DNA damaged” nucleosides (e.g., 8-Oxo-2'-deoxyguanosine, NACR1-292; 8-Oxo-2'-deoxyadenosine, NACR1-291)