1-(β-D-2-Deoxyribofuranosyl)-3-nitropyrrole
CAS No.:157066-48-3
Modified nucleoside synthon.
1-(β-D-2-Deoxyribofuranosyl)-3-nitropyrrole
5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine
CAS No.:115794-55-3
Modified nucleoside synthon.
5-[N-(2-(Trifluoroacetamido)ethyl)-3-(E)-acrylamido]-2'-deoxyuridine
CAS No.:869222-69-5
Modified nucleoside synthon.
5-Carboethoxy-2'-deoxycytidine
CAS No.:1210427-55-6
Modified nucleoside synthon.
5'-O-Dimethoxytrityl-2-fluoro-6-O-(2-(4-nitrophenyl)ethyl)-2'-deoxyinosine
CAS No.:153527-28-7
Modified nucleoside synthon.
5-Iodo-2'-deoxyuridine
CAS No.:54-42-2
Modified nucleoside synthon.
Pseudouridine (Fermentation)
CAS No.:1445-07-4
Fermented nucleoside synthon of the common RNA modification.
tC Nucleoside
CAS No.:162902-04-7
Modified nucleoside synthon.
5,6-Dihydro-5-aza-2'-deoxycytidine
CAS No.:114522-16-6
Synthon useful in antiviral studies.
2'-O-Methyluridine
CAS No.:2140-76-3
Modified nucleoside synthon.
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Modified Nucleosides
Modified nucleosides are useful building blocks for DNA and RNA synthesis because they can alter the stability, function, and utility of an oligo, making them useful for a variety of applications.
Our uniquely large collection of modified nucleosides offers a diversity of properties such as fluorescence (e.g., Pyrrolo-dC, NACR1-350), immunostimulation (e.g., 5-Amino-3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(3H,6H)-dione, NACR1-366), enzyme inhibition (e.g., Tricyclic Nucleoside Monophosphate, NACR1-362), and altered base-pairing (2'-Deoxyisoguanosine, NACR1-071).
Highlights of modified nucleosides within our collection include:
- Bromo- and Iodo-modified nucleoside phosphoramidite precursors (Bromo: NACR1-001, NACR1-003; Iodo: NACR1-002, NACR1-004)
- 5-Hydroxymethyl-2'-deoxycytidine (NACN4-007), 5-Formyl-2’-deoxycytidine (NACN4-003), and 5-Hydroxy-2'-deoxycytidine (NACN4-004) for epigenetic studies
- Family of Pseudouridine analogues including Pseudouridine (Fermentation NACR1-348; Synthetic NACR1-368) and N1-Methypseudouridine (NACR1-311)
- Unnatural bases (dNaM, NACR1-304; d5SICS, NACR1-302) for expanding the genetic alphabet and “DNA damaged” nucleosides (e.g., 8-Oxo-2'-deoxyguanosine, NACR1-292; 8-Oxo-2'-deoxyadenosine, NACR1-291)