Skip to content Skip to navigation menu

1,N2-Etheno-dG CE-Phosphoramidite

1,N2-Etheno-dG CE-Phosphoramidite

This phosphoramidite allows incorporation of an etheno bridged dG moiety internally or at the 5’ end of an oligonucleotide.
Option 1: Select a Size
Option 2: Select a Bottle Type
TBD
Add to basket to request a quote

Product information

The etheno bridged ring system results from the reaction of vinyl halide and other vinyl monomer electrophiles with dG, dC or dA nucleotides in DNA.(1) Research has shown that the 1,N2-etheno dG is mutagenic in both E. coli and mammalian cells.(2) The structure of duplex DNA containing 1,N2-etheno dG has been studied and shown to hinder canonical Watson-Crick H-bonding.(3)

Ref:

  1. Barbin, A. Mutat. Res. 2008, 462, 55-69.
  2. Shanmugam, G.; Kozekov, I. D.; Guengerich, F. P.; Rizzo, C. J.; Stone, M. P. Chem. Res. Toxicol. 2008, 21, 1795-1805.
  3. (a) Shanmugam, G.; Goodeneough, A.K.; Kozekov, I. D.; Guengerich, F. P.; Rizzo, C. J.; Stone, M. P. Chem. Res. Toxicol., 2007, 20(11), 1601-1611. (b) Stone, M. P.; Huang, H.; Brown, K. L.; Shanmigam, G. Chemistry & Biodiversity, 2011, 8, 1571-1615.
Brand Berry
Type Phosphoramidites
Base dG
Sequence Internal

Access support

Need some support with placing an order, setting up an account, or finding the right protocol?

Contact us