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G-Rich regions in nucleic acids often display disrupted Watson-Crick base-pairing due to the ability of dG and G residues to enter into non-Watson-Crick inter- and intramolecular hydrogen bonding. A solution to this problem is to replace the N7 nitrogen atom on the guanine nucleobase with a CH group, obviating the possibility of hydrogen bonding at that position.(1) We have long offered 7-Deaza-dG CE-Phosphoramidite (BA0008), and now also offer this RNA analogue for oligoribonucleotide synthesis.
- Seela, F.; Driller, H. Nucleic Acids Res. 1989, 17(3), 901-910.