7-Deaza-dA CE-Phosphoramidite
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7-Deaza-dA CE-Phosphoramidite
7-Deaza-dA CE-Phosphoramidite, BULK (g), Glass Screw-Top
CAS No.:107134-59-8
Useful phosphoramidite for modification of base pairing and metal chelating characterisitcs of purine nucleosides through elimination of the N7 nitrogen.
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Product information
The N7 imidazole nitrogen of purine nucleosides is known to take part in non-Watson-Crick hydrogen bonding and in metal chelation. "Deleting" the N7 nitrogen by replacing it with a CH group is a useful modification that has been accomplished in DNA oligonucleotides using the phosphoramidite of 2'-deoxytubercidin, namely 7-Deaza-dA CE-Phosphoramidite,(1), which was useful in showing that N7 of dA is an important hydrogen bond acceptor site for the endodeoxyribonuclease EcoRI.
Ref:
- (a) Seela, F.; Kehne, A. Biochemistry, 1987 26, 2232-2238. (b) Seela, F.; Berg, H.; Rosemeyer, H. Biochemistry, 1989, 28, 6193-6198.
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