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5-(2-Furyl)-dU CE-Phosphoramidite

5-(2-Furyl)-dU CE-Phosphoramidite

CAS No.: 863713-51-3

Small, fluorescent natural base mimic that can signal the presence of abasic sites in hybridized DNA oligonucleotides.
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5-(2-Furyl)-dU CE-Phosphoramidite is a phosphoramidite of a small, fluorescent nucleoside that is an isosteric mimic of thymidine.(1) This probe has been shown to pair with adenine to form a stable duplex. DNA probes constructed to contain this moiety at a selected sequence position show a significant emission enhancement when hybridization results in an opposing abasic residue as compared to an opposing adenine residue.1a This property makes BA0346 useful for the preparation of probes that are designed to detect sequence-specific depurination and depyrimidination.

Ref:

  1. (a) Greco, N.J.; Tor, Y. J. Am. Chem. Soc. 2005, 127, 10784-10785. (b) Greco, N.J.; Tor, Y. Nature Protocols, 2007, 2, 305-316.
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