Photochromic nucleoside (PCN) phosphoramidite that provides reversible duplex regulation via a light induced trans-cis isomerization.
Useful for incorporating 7-Deaza-modified guanosine into oligonucleotides to disrupt unwanted hydrogen bonding.
A phosphoramidite that is an isosteric analogue of dG.
Useful phosphoramidite tool for investigations of duplex stabilization as a result of substituents on the purine scaffold.
Smallest member of the "steric phosphoramidite tool box" for probing the steric requirements at N2 of dG in various applications.
Phosphoramidite for internal or 5'-incorporation of a deaza-modified dG nucleobase into an oligonucleotide.
Phosphoramidite with applications in enzymatic and chemical methylation, as well as Tm-leveling studies.
Phosphoramidite for the incorporation of a residue into oligonucleotides that mimics protonated cytosine for studies on triple helix formation.
Modified Oligo Synthesis Reagents
With our extensive library of reagents, you can synthesise oligos with your modification of choice—from conjugation chemistry to cell delivery to probe detection, we’ve got you covered.
LGC, Biosearch Technologies offers 1000+ phosphoramidites, nucleosides, solid supports and expert knowledge to ensure you can find exactly what you need to synthesise the ideal oligonucleotide and achieve your project goals faster.
Our wide range of reagents with unrivaled quality provides a single source for your oligonucleotide synthesis reagents—simplifying your supply chain so you can focus on your science and accelerate your path forward.
Increase oligo duplex stability with high-quality amidites and reagents for backbone modifications.
Create oligonucleotide dendrimers that can be used to amplify signals in hybridisation tests or to build various nanostructures.
|Cell delivery and uptake
Incorporate our lipophilic, vitamin, and GalNAc moieties into your oligos to enhance cell delivery and uptake.
Synthesise oligonucleotides containing a 5’ or 3’-phosphate group with our phosphoramidites, CPGs and synthesis columns.
|Colourimetric detection and capture
Generate reliable hapten labelled probes with our biotinylation and DNP reagents.
Incorporate reactive functional groups within your oligo to allow for subsequent post-synthesis conjugation with your label of choice.
Prepare electrochemical oligo probes for nucleic acid analysis using ferrocene or methylene blue as the signaling redox moiety.
|Fluorophores and quenchers
From gold-standard quenching reagents to our patented dyes, find the phosphoramidite, solid support and reagents you need to generate the ideal fluorescent signal.
|Modifications for nuclease resistance
Protect your DNA and RNA oligos from nucleases by incorporating 2’-O-Methyl and 2’-Fluoro modifications, or enable “reverse” oligo synthesis.
Incorporate a photocleavable terminal modification or mid-sequence linker/spacer with our modified phosphoramidites incorporating photo-cleavable linkers.
Get the functionality and design you need by incorporating single- or multi-carbon, -sugar, or -atom spacers into your oligo.
Create oligos to induce mutagenic effects, study epigenetic pathways, improve duplex stabilities and more with our extensive list of structural modifiers.